Clinical study of correlation between 25-(OH)D and children with type 1 diabetes mellitus and diabetic ketoacidosis

Objective To study the correlation between the levels of serum 25-(OH)D and the children with type 1 diabetes mellitus(T1DM)and diabetic ketoacidosis(DKA).Methods Fifty-two cases with newly diagnosed T1DM were selected from 152 cases who stayed in hospital from January 2006 to November 2009,21 cases with DKA and 31 cases without DKA.One hurdred children excluded from T1DM according to the standard of T1DM were was selected.Serum 25-(OH)D was measured and compared among three groups.The relationship between the levels of serum 25-(OH)D and the children with T1DM,DKA was analyzed.Results The levels of serum 25-(OH)D in cases with DKA(53.6 ± 27.8 nmol/L)were lower than those in cases without DKA(69.7 ± 27.9 nmol/L)and children without T1DM(81.8 ± 28.3 nmol/L)(P 0.05).The levels of serum 25-(OH)D in cases without DKA were lower than those in children without T1DM(P 0.05).Conclusions The levels of serum 25-(OH)D in children with T1DM are low,especially in children with DKA.The potential protective effect of 25-(OH)D on the development of T1DM should be noticed.