Using the method of modeling indoor, the sensitivity of different maize varieties to sulfonylurea herbicides was studied. In addition, with the method of planting in pot, the effect of sulfonylurea herbicides to sensitive maize varieties in seedling was observed. The results showed that there were different sensitivity to sulfonylurea herbicides among different maize varieties. The concentration of sulfonylurea herbicides in soil beyond ED 50 /50 had clearly effect on length of roots、hight of plants、area of leaves in maize seedling stage.