Effect of Tongxi Powder on blood uric acid of mice with acute hyperuricemia

Objective To investigate the effect of Tongxi Powder(TP) on decreasing the uric acid of mice with acute hyperuricemia.Methods The mice were divided into model,allopurinol(positive control,10 mg/kg),low-,mid-,and high-dose(100,300,and 500 mg/kg) TP groups.Except the model group,mice in other groups were administered once daily for 3 d.The acute hyperuricemia model of mice was established 2 h after the last administration and then ip uric acid(450 mg/kg),and the blood uric acid contents were determined after 80 min.Results Compared with the model group,TP at mid-and high-dose could obviously decrease the blood uric acid level in mice(P 0.01),so did allopurinol(P 0.01).The effect of high-dose TP group was the same as that of allopurinol group.Conclusion TP could inhibit the increase of blood uric acid in mice with acute hyperuricemia.