The role of the TGF-β pseudoreceptor Bambi in a mouse model of allergic bronchial asthma

Introduction: Allergic bronchial asthma is characterized by chronic inflammation and airway remodeling, which are linked to airway hyperresponsiveness (AHR) and impaired lung function. Transforming Growth Factor beta (TGF-β) is an important anti-inflammatory factor but with persistence of inflammation it mediates structural changes of the airways.