Investigation of processing technology of zedoary turmeric oil-cyclo dextrin inclusion compound

[Objective] To compare the inclusion effect of different types of cyclodextrin(α- cyclodextrin,β- cyclodextrin,γ- cyclodextrin) on zedoary turmeric oil,study the best preparation technology of zedoary turmeric oil and cyclodextrin inclusion compound.[Methods] Using the saturated water solution method,α-cyclodextrin,β-cyclodextrin,γ-cyclodextrin zedoary turmeric oil inclusion compound were prepared and using X ray diffraction method the inclusion effect was identified;using L9(34) orthogonal experimental design,the best preparation technology of zedoary turmeric oil and cyclodextrin inclusion compound was optimized.[Results] Under the same conditions,α-cyclodextrin and zedoary turmeric oil could not form inclusion compound,the inclusion rate of γ-cyclodextrin and β-cyclodextrin inclusion rate were almost the same.Taking the inclusion rate and oil utilizing rate as the indexes,the optimum process of zedoary turmeric oil and β-cyclodextrin inclusion compound was 8∶1 of A3B1C2: β-cyclodextrin: Oil(g/mL),the inclusion temperature was 40 ℃ and the inclusion time was 90 min.According to the best prescription process parameters 3 experiments were repeatedly performed.It was found that the volatile oil inclusion rate was 90.90% and the oil utilizing rate was 66.67%,RSD2.7%.The results showed that physical mixture of X ray spectrum was different between inclusion complexes with cyclodextrins and volatile oil with cyclodextrin.[Conclusion] The technology is reasonable and the cost can be saved when selecting β-cyclodextrin inclusion zedoary turmeric oil.