Objective To decrease negative laparotomy in patients suffering from penetrating abdominal wounds. Methods The clinical data of 121 patients of penetrating abdominal wounds undergoing exploratory laparotomy form Jun. 1997 to Oct. 2004 were retrospectively reviewed. Results As absolutely acute indications of patients suffering from penetrating abdominal wounds, the rate of negative laparotomy was 32.2%(39/121). Conclusions None all of the patients suffering from penetrating abdominal wounds need acute operation. The rational acute indications effectively decrease the negative laparotomy