Enhanced solubility of paeonolum with different types of cyclodextrins by phase solubility method

The phase solubility curves of paeonolum(PAE) were obtained by determining the solubility of paeonolum in different concent rations of β-CD and it's derivatives(HP-β-CD、HE-β-CD、SBE4-β-CD and SBE7-β-CD at different temperatures.The experimental results indicated that the phase solubility curves of paeonolum in five different cyclodextrins were AL styles and the inclusion ratio of paeonolum versus cyclodextrins was 1∶1.PAE solubility in the water can be improved by introducing CD derivatives into the system.The best enhancing effect of paeonolum solubility was SBE7-β-CD.