Diuretic Effects of Acetazolamide, Furosemide and Hydroflumethiazide in Cows

The diuretic effects of acetazolamide (5.0mg/kg), furosemide (0.5mg/kg), and hydroflumethiazide (1.0mg/kg) were investigated in cows by means of a clearance method.Acetazolamide revealed temporary and slight increases in sodium clearance, potassium clearance, and urine volume. The chloride clearance was persistently decreased. Furosemide revealed significant increases in sodium clearance, potassium clearance, chloride clearance, and urine volume. However, it showed transient diuretic effects in cows. Hydroflumethiazide revealed mild effects compared with furosemide, although persistent increases in sodium clearance, potassium clearance, chloride clearance, and urine volume were observed.