骨髓
间质细胞
造血
间充质干细胞
骨髓增生异常综合症
干细胞
癌症研究
医学
病理
免疫学
生物
细胞生物学
作者
Gao-Chao Zhang,Huaquan Wang,Zonghong Shao
出处
期刊:PubMed
日期:2016-02-01
卷期号:24 (1): 290-4
标识
DOI:10.7534/j.issn.1009-2137.2016.01.056
摘要
Myelodysplastic syndromes (MDS) are a group of bone marrow failure diseases. The bone marrow microenvironment consists of bone marrow stromal cells (BMSC), growth factors and cytokines. The BMSC supporting haemopoiesis include mesenchymal stem cells (MSC), osteoblasts, endothelial cells and macrophages, but the adipocytes play a role in the suppression of hematopoiesis. Recently more and more researches indicate that the abnormality of bone marrow microenvironment involves in the pathogenesis and progression of MDS. In this review the abnormality of MDS bone marrow microenvironment is summarized briefly.
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