OBJECTIVE: To explore effective components from Paeonia suffruticosa. METHODS: The extraction technology was optimized by orthogonal design with mass fraction of paeonol and paeoniflorin as index using the concentration and volume of ethanol, extraction time as factors. RESULTS: The optimized technology was as follows: 15-folds 65% ethanol and extracting for 1 min by tissue-breaking method. CONCLUSIONS: Optimized technology is simple, feasible and high extraction, which is suitable for the extraction of paeonol and paeoniflorin from P. suffruticosa.