Eight lanthanide oxides were added to Mo-Bi-O c atalysts for the selective oxidation of isobutene to methacrolein and the influence of reaction temperature, concentration of isobutene in the reactant gases and RE2O3 proportion in the Mo-Bi-O catalysts on the conversion of isobutene and selectivity to methacrolein was studied in the fixed bed reactentThe experiments showed that the concentration of isobutene and selectivity of isobutene oxidation to methacrolein was improved by adding CeO2,Eu2O3 and Tb4O7