Chromosome Conformation Capture and its Development

The widely dispersed genes and their regulatory elements often form complex three-dimensional networks to regulate gene expression.The chromosome conformation capture is a robust new assay for the study of the long-range chromatin interactions.We introduced the basic principle and process of chromosome conformation cap-ture and its recently new derivates,with the mainly focused on the advantages,disadvantages and the prospect of present genome-wide version of chromosome conformation capture,the genome conformation capture,Hi-C and the ChIA-PET(chromatin-interaction analysis by paired-end tag sequencing).