Research Advances of HSP27′s Role in Cardiovascular Diseases

HSP27 is an important member of small molecular weight heat shock protein(HSP) family,the external stimulation of free radicals,heat,ischemic and toxic substances can induce the generation of HSP27 in the cell,presenting high expression in a variety of tumors and normal tissues,with especially high expression in cardiac tissue,which have a positive effect in the anti-apoptosis,anti-ischemia injury and anti-inflammatory.It has a regulatory role in the vascular smooth muscle cell proliferation and migration and the occurrence and development of atherosclerosis.HSP27 may be a new therapeutic strategy of cardiovascular diseases.