[The metabolism of TMPz in vivo].

The metabolism of tetramethylpyrazine (TMPz) in rats was investigated. Deuterated TMPz and unlabelled TMPz were administered by intragastric perfusion to two rats, respectively. Extracts from urine samples were analyzed within 24h by gas chromatography/mass spectrometry (GC/MS). By applying the ion cluster technique, TMPz and its three metabolites were identified.