CD137
单核细胞
细胞生物学
肿瘤坏死因子α
受体
信号转导
化学
生物
分子生物学
T细胞
免疫学
生物化学
免疫系统
作者
Joachim Langstein,Jan Michel,Jana Fritsche,Marina Kreutz,Reinhard Andreesen,Herbert Schwarz
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1998-03-01
卷期号:160 (5): 2488-2494
被引量:163
标识
DOI:10.4049/jimmunol.160.5.2488
摘要
CD137 (ILA/4-1BB), a member of the TNF receptor family, was shown previously to inhibit proliferation and to induce apoptosis in T lymphocytes. In this study, we identify CD137 as a novel and potent monocyte activation factor. CD137 protein induces expression of IL-6, IL-8, and TNF-alpha, and inhibits expression of IL-10. Furthermore, CD137 differentially regulates expression of cell surface receptors. It induces expression of ICAM and reduces expression of FcgammaRIII, while levels of HLA-DR remain unchanged. CD137 also promotes adherence of monocytes. These effects of CD137 require immobilization of CD137 protein, indicating that they are mediated by cross-linking of a corresponding ligand/coreceptor expressed on monocytes.
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