组织病理学
脂肪性肝炎
脂肪肝
发病机制
肝硬化
脂肪变性
医学
病理
内科学
代谢综合征
肝病
疾病
流行病学
胃肠病学
肥胖
作者
Adam P Levene,Robert Goldin
出处
期刊:Histopathology
[Wiley]
日期:2012-02-28
卷期号:61 (2): 141-152
被引量:168
标识
DOI:10.1111/j.1365-2559.2011.04145.x
摘要
Levene A P & Goldin R D (2012) Histopathology 61, 141–152 The epidemiology, pathogenesis and histopathology of fatty liver disease Fatty liver disease includes non‐alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), each of which is increasing in prevalence. Each represents a histological spectrum that extends from isolated steatosis to steatohepatitis and cirrhosis. NAFLD is associated with obesity, diabetes, and insulin resistance, and is considered to be the liver manifestation of the metabolic syndrome. The pathogenesis of NAFLD and ALD involves cytokines, adipokines, oxidative stress, and apoptosis. Histopathology is the gold standard for assessing the severity of liver damage in NAFLD and ALD. We have reviewed the literature, and described and compared the epidemiology, natural disease history, pathogenesis and histopathology of NAFLD and ALD.
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