清脆的
生物
反式激活crRNA
背景(考古学)
Cas9
基因组编辑
生物发生
计算生物学
回文
获得性免疫系统
引导RNA
适应(眼睛)
流动遗传元素
基因组
基因组工程
遗传学
基因
CRISPR干扰
细胞生物学
免疫系统
神经科学
古生物学
作者
Frank Hille,Hagen Richter,Shi Pey Wong,Majda Bratovič,Sarah Ressel,Emmanuelle Charpentier
出处
期刊:Cell
[Elsevier]
日期:2018-03-01
卷期号:172 (6): 1239-1259
被引量:668
标识
DOI:10.1016/j.cell.2017.11.032
摘要
In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system against phages and other foreign genetic elements. Here, we review the biology of the diverse CRISPR-Cas systems and the major progress achieved in recent years in understanding the underlying mechanisms of the three stages of CRISPR-Cas immunity: adaptation, crRNA biogenesis, and interference. The ecology and regulation of CRISPR-Cas in the context of phage infection, the roles of these systems beyond immunity, and the open questions that propel the field forward are also discussed.
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