共轭体系
化学发光
鲁米诺
光动力疗法
光化学
化学
纳米颗粒
聚合物
发光
氧气
活性氧
血红蛋白
纳米技术
材料科学
有机化学
光电子学
生物化学
作者
Linye Jiang,Haotian Bai,Libing Liu,Fengting Lv,Xueqin Ren,Shu Wang
标识
DOI:10.1002/anie.201905884
摘要
Abstract Photodynamic therapy (PDT) is a promising method for cancer treatment. Two parameters that influence the efficacy of PDT are the light source and oxygen supply. Herein, we prepared a system for PDT using hemoglobin (Hb)‐linked conjugated polymer nanoparticles (CPNs), which can luminesce and supply oxygen. Hb catalyzes the activation of luminol, the conjugated polymer poly[2‐methoxy‐5‐(2‐ethylhexyloxy)‐1,4‐phenylenevinylene] (MEH–PPV) nanoparticles can absorb the chemiluminescence of luminol through chemiluminescence resonance energy transfer (CRET) and then sensitize the oxygen supplied by Hb to produce reactive oxygen species that kill cancer cells. This system could be used for the controlled release of an anticancer prodrug. The system does not need an external light source and circumvents the insufficient level molecular oxygen under hypoxia. This work provides a proof‐of‐concept to explore smart and multifunctional nanoplatforms for phototherapy.
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