透皮
阿霉素
渗透(战争)
体内分布
药物输送
角质层
生物相容性
材料科学
毒品携带者
生物利用度
药品
纳米技术
生物医学工程
药理学
化学
医学
病理
化疗
体外
生物化学
冶金
外科
工程类
运筹学
作者
Christian Wiraja,Ying Zhu,Daniel Chin Shiuan Lio,David Yeo,Mo Xie,Weina Fang,Qian Li,Mengjia Zheng,M.A.M. van Steensel,Lihua Wang,Fan Chen,Chen Xu
标识
DOI:10.1038/s41467-019-09029-9
摘要
DNA nanostructures are promising drug carriers with their intrinsic biocompatibility, uniformity and versatility. However, rapid serum disintegration leads to low bioavailability at targeted sites following systemic administration, hindering their biomedical applications. Here we demonstrate transdermal delivery of framework nucleic acids (FNAs) through topical applications. By designing FNAs with distinct shapes and sizes, we interrogate their penetration on mice and human skin explant. Skin histology reveals size-dependent penetration, with FNAs ≤75 nm effectively reaching dermis layer. 17 nm-tetrahedral FNAs show greatest penetration to 350 µm from skin periphery. Importantly, structural integrity is maintained during the skin penetration. Employing a mouse melanoma model, topical application of doxorubicin-loaded FNAs accommodates ≥2-fold improvement in drug accumulation and tumor inhibition relative to topically-applied free doxorubicin, or doxorubicin loaded in liposomes and polymeric nanoparticles. Programmable penetration with minimal systemic biodistribution underlines FNA potential as localized transdermal drug delivery carriers.
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