丝胶
丝绸
羧甲基纤维素
纤维素
傅里叶变换红外光谱
家蚕
材料科学
壳聚糖
极限抗拉强度
化学工程
接触角
化学
粘附
高分子化学
核化学
复合材料
有机化学
生物化学
钠
工程类
基因
作者
Peng Wang,Huawei He,Rui Cai,Gang Tao,Meirong Yang,Hua Zuo,Ahmad Umar,Yejing Wang
标识
DOI:10.1016/j.carbpol.2019.02.069
摘要
Developing biomaterials based on the natural biomacromolecule silk sericin from Bombyx mori cocoon is of great interest for biomedical application. Dialdehyde carboxymethyl cellulose (DCMC) is derived from periodate oxidation of carboxy- methyl cellulose. Here, we developed a novel strategy of cross-linking of sericin with DCMC via the Schiff’s base reaction. Fourier transform infrared spectroscopy and scanning electron microscopy indicated the formation of Schiff’s base via the blending of sericin and DCMC. The mechanical properties tests suggested the covalent cross-linking effectively enhanced the tensile strength of sericin. The swelling test and water contact angle indicated the DCMC/SS film had excellent hydrophilicity, swellability. Additionally, we demonstrated the DCMC/SS film had excellent blood compatibility, cytocompatibility and promoting cell proliferation activity by the hemolysis ratio analysis, cell adhesion, cells viability and proliferation assays. The prepared DCMC/SS film has shown great promise in biomedical applications such as wound dressing, artificial skin and tissue engineering.
科研通智能强力驱动
Strongly Powered by AbleSci AI