红树林
立体化学
化学
细胞毒性
肺孢子虫病
圆二色性
真菌
溴
植物
生物
有机化学
生物化学
体外
生态学
作者
Yan Chen,Wencong Yang,Ge Zou,Guisheng Wang,Wenyi Kang,Jie Yuan,Zhigang She
标识
DOI:10.1021/acs.jnatprod.1c01115
摘要
Twelve new cytochalasins, phomopchalasins D-O (1-3, 5-12, and 14), including one brominated (2) and two iodinated cytochalasins (3 and 6), together with six known analogues (4, 13, and 15-18) were isolated from the mangrove-derived fungus Phomopsis sp. QYM-13 treated with 3% NaBr or 3% KI in potato liquid medium. Their structures and absolute configurations were established by extensive spectroscopic analysis (1D and 2D NMR, HRESIMS), electronic circular dichroism calculations, and a single-crystal X-ray diffraction experiment. Compounds 3 and 6 represent the first iodinated cytochalasins. Compounds 2, 15, 17, and 18 exhibited significant cytotoxicity against human cancer cell line MDA-MB-435 with IC50 values ranging from 0.2 to 8.2 μM.
科研通智能强力驱动
Strongly Powered by AbleSci AI