PSMD12-Mediated M1 Ubiquitination of Influenza A Virus at K102 Regulates Viral Replication

M1 is proposed to play multiple biologically important roles in the life cycle of IAV, which relies largely on host factors. This study is the first one to identify that PSMD12 interacts with M1, mediates K63-linked ubiquitination of M1 at the K102 site, and thus positively regulates influenza virus proliferation.