材料科学
涂层
基质(水族馆)
表面改性
图层(电子)
植酸
化学工程
粘附
钛
制作
复合材料
纳米技术
冶金
化学
病理
替代医学
工程类
地质学
海洋学
医学
生物化学
作者
Xiaodong He,Jieyu Zhang,Liwei Xie,Gnanasekar Sathishkumar,Chunmei Li,Xi Rao,Jing Zhao,Kai Zhang,Rui Wang,E. T. Kang,Liqun Xu
标识
DOI:10.1016/j.cej.2022.135917
摘要
Surface modification or reconstruction of biomaterials, medical devices or other materials hold great promise for improved functionality and applications. However, it is essential to develop coating layers possessing a wide range of functionalities, such as antibacterial, anticorrosive and biocompatible properties. In this work, a simplified method was investigated for the supramolecular assembly of natural bio compounds, phytic acid (PA) and antimicrobial peptide of ε-polylysine (Ply), via one-pot co-deposition. The PA and Ply formed a coating layer on the substrate surface through the inherent surface affinity of PA and ionic bond formation between the electro-positive Ply and electro-negative PA. The co-deposition of PA-Ply is a surface-independent. The physio-chemical features of PA-Ply on titanium (Ti) were characterized to reveal the polymer decoration, surface composition, and microtopography. It was noticed that the PA-Ply coating on Ti (Ti-PA-Ply) could kill greater than 99.9% of both Gram-positive and Gram-negative bacterial pathogens upon their adhesion as compared to that of the pristine Ti surface. Furthermore, the in vivo rat subcutaneous infection model demonstrated effective anti-infection and bactericidal properties of the Ti-PA-Ply surface. In addition, the PA-Ply coating exhibited anti-corrosive property for medical-grade magnesium (Mg) in an electrochemical corrosion model, and promoted the proliferation of endothelial cells. The versatile PA-Ply coating also imparted an improved anti-fogging performance. Thus, the present one-step co-depostition of PA-Ply provided a simple, envirementelly-benign and sustainable approach to the design and fabrication of multi-functional surfaces.
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