衣壳
诺沃克病毒
杯状病毒
猫杯状病毒
杯状病毒科
病毒学
生物
细小病毒科
病毒
病毒蛋白
结晶学
细小病毒
化学
病毒性疾病
诺如病毒
作者
B. V. Venkataram Prasad,Michele E. Hardy,Terje Dokland,Jordi Bella,Michael G. Rossmann,Mary K. Estes
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1999-10-08
卷期号:286 (5438): 287-290
被引量:850
标识
DOI:10.1126/science.286.5438.287
摘要
Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure. The capsid protein has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that has a classical eight-stranded beta-sandwich motif. The structure of the P domain is unlike that of any other viral protein with a subdomain exhibiting a fold similar to that of the second domain in the eukaryotic translation elongation factor-Tu. This subdomain, located at the exterior of the capsid, has the largest sequence variation among Norwalk-like human caliciviruses and is likely to contain the determinants of strain specificity and cell binding.
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