哌嗪
化学
取代基
喹啉
抗菌活性
立体化学
体内
组合化学
药物化学
有机化学
细菌
遗传学
生物
生物技术
作者
Daniel T. W. Chu,Akiyo Claiborne,Jacob J. Clement,Jacob J. Plattner
摘要
A series of quinoline and naphthyridine antibacterial agents possessing an acyclic or cyclic gem-disubstituted piperazine substituent at the C-7 position have been prepared and evaluated in vitro and in vivo for antibacterial activity against a variety of Gram-positive and Gram-negative organisms. They are, however, not as active as quinolones or naphthyridines with a monosubstituted piperazine substituent at C-7. The chemical synthesis of these derivatives is also described.
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