亮氨酸拉链
DNA
bZIP域
生物
核蛋白
信使核糖核酸
基因
碱性螺旋-环-螺旋-亮氨酸拉链转录因子
肽序列
分子生物学
生物化学
遗传学
DNA结合蛋白
转录因子
作者
William Landschulz,Peter F. Johnson,Steven L. McKnight
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1989-03-31
卷期号:243 (4899): 1681-1688
被引量:624
标识
DOI:10.1126/science.2494700
摘要
C/EBP is a rat liver nuclear protein capable of sequence-specific interaction with DNA. The DNA sequences to which C/EBP binds in vitro have been implicated in the control of messenger RNA synthesis. It has therefore been predicted that C/EBP will play a role in regulating gene expression in mammalian cells. The region of the C/EBP polypeptide required for direct interaction with DNA has been identified and shown to bear amino acid sequence relatedness with the product of the myc, fos, and jun proto-oncogenes. The arrangement of these related amino acid sequences led to the prediction of a new structural motif, termed the "leucine zipper," that plays a role in facilitating sequence-specific interaction between protein and DNA. Experimental tests now provide support for the leucine zipper hypothesis.
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