药物发现
生物信息学
药品
计算生物学
交互网络
蛋白质相互作用网络
药物靶点
业务流程发现
计算机科学
生物信息学
系统生物学
蛋白质-蛋白质相互作用
生物
药理学
业务流程
基因
地质学
业务流程建模
生物化学
相容性(地球化学)
遗传学
地球化学
作者
Chiranjib Chakraborty,George Priya Doss. C,Luonan Chen,Hailong Zhu
出处
期刊:Current Protein & Peptide Science
[Bentham Science]
日期:2014-07-23
卷期号:15 (6): 561-571
被引量:19
标识
DOI:10.2174/1389203715666140724090153
摘要
In silico pharmacology is a promising field in the current state-of drug discovery. This area exploits "protein-protein Interaction (PPI) network analysis for drug discovery using the drug "target class". To document the current status, we have discussed in this article how this an integrated system of PPI networks contribute to understand the disease pathways, present state-of-the-art drug target discovery and drug discovery process. This review article enhances our knowledge on conventional drug discovery and current drug discovery using in silico techniques, best "target class", universal architecture of PPI networks, the present scenario of disease pathways and protein-protein interaction networks as well as the method to comprehend the PPI networks. Taken all together, ultimately a snapshot has been discussed to be familiar with how PPI network architecture can used to validate a drug target. At the conclusion, we have illustrated the future directions of PPI in target discovery and drug-design.
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