吞噬作用
中性粒细胞胞外陷阱
细胞外
免疫系统
细胞生物学
生物物理学
纳米颗粒
化学
炎症
纳米毒理学
粒子(生态学)
纳米技术
免疫学
生物
材料科学
生态学
作者
Matthias Bartneck,Heidrun A. Keul,Gabriele Zwadlo-Klarwasser,Jürgen Gröll
出处
期刊:Nano Letters
[American Chemical Society]
日期:2009-12-08
卷期号:10 (1): 59-63
被引量:168
摘要
It has recently been discovered that human immune cells, especially neutrophil granulocytes, form neutrophil extracellular traps (NETs) that abolish pathogens. Our study provides evidence that extracellular traps formed by neutrophils, monocytes and macrophages act as physical barriers for nanoparticles, thus presenting a new nanomaterial clearance mechanism of the human immune system. While particle shape is of minor importance, positive charges significantly enhance particle trapping.
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