热休克蛋白
海龟(机器人)
下调和上调
休克(循环)
脑功能
缺氧水域
生物
神经科学
细胞生物学
化学
内科学
医学
基因
生物化学
生态学
作者
Howard Prentice,Sarah L. Milton,Daniela Scheurle,Peter L. Lutz
标识
DOI:10.1097/01.wcb.0000126565.27130.79
摘要
Because heat shock proteins (HSPs) have an important protective function against ischemia/anoxia in mammalian brain, the authors investigated the expression of Hsp72 and Hsc73 in the anoxia-surviving turtle brain. Unlike the mammalian brain, high levels of Hsp72 were found in the normoxic turtle brain. Hsp72 levels were significantly increased by 4 hours of anoxia, remained constant until 8 hours, and then decreased to baseline at 12 hours. By contrast, Hsc73 was progressively increased throughout 12 hours of anoxia. This differential expression suggests different protective roles: Hsp72 in the initial downregulatory transition phase, and Hsc73 in maintaining neural network integrity during the long-term hypometabolic phase.
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