长时程增强
神经科学
海马体
海马结构
神经传递
抑制性突触后电位
刺激
谷氨酸受体
LTP诱导
NMDA受体
化学
突触可塑性
生物
心理学
受体
兴奋性突触后电位
生物化学
作者
Jonathan R. Whitlock,Arnold J. Heynen,Marshall G. Hussain Shuler,Mark F. Bear
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2006-08-25
卷期号:313 (5790): 1093-1097
被引量:1691
标识
DOI:10.1126/science.1128134
摘要
Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts have been motivated by the belief that similar synaptic modifications occur during memory formation, but it has never been shown that learning actually induces LTP in CA1. We found that one-trial inhibitory avoidance learning in rats produced the same changes in hippocampal glutamate receptors as induction of LTP with HFS and caused a spatially restricted increase in the amplitude of evoked synaptic transmission in CA1 in vivo. Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1.
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