蜕膜
流式细胞术
表型
免疫系统
免疫学
生物
巨噬细胞
免疫组织化学
吞噬作用
细胞生物学
胎儿
胎盘
怀孕
体外
基因
生物化学
遗传学
作者
Kristijan Čupurdija,Dagmar Azzola,Ursula Hainz,Alexei Gratchev,Andreas Heitger,Osamu Takikawa,Sergij Goerdt,Reinhold Wintersteiger,Gottfried Dohr,Peter Sedlmayr
标识
DOI:10.1046/j.8755-8920.2003.00128.x
摘要
Depending on the type of their activation, macrophages may promote TH1- or TH2-type of immune responses. To date, not much is known about the activation phenotype of decidua macrophages, which - together with NK cells - constitute the majority of bone marrow derived cells at this location.The study was based on analysis of healthy first trimester decidua by immunohistochemistry and flow cytometry. We analyzed expression of markers characteristic for alternatively activated macrophages (Mphi2).The markers MS-1 (stabilin-1) and coagulation factor XIIIa were found expressed in the interior of decidua macrophages (DMphi). In contrast, indoleamine 2,3-dioxygenase (IDO), an enzyme induced in macrophages by IFNgamma, was not present in DMphi.First trimester DMphi display phenotypic markers associated to alternatively activated macrophages. In addition, absence of IDO indicates that DMphi are not under a predominant influence of IFNgamma.
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