Catalytic Asymmetric Cross‐Aza‐Benzoin Reactions of Aliphatic Aldehydes with N‐Boc‐Protected Imines

Crossed: A catalyst system has been developed that allows the direct asymmetric coupling of aliphatic aldehydes and N-Boc-protected imines in a cross-aza-benzoin reaction (see scheme; Boc=tert-butoxycarbonyl). The active catalyst is shown to react rapidly with the imine, however, the presence of an acid as co-catalyst renders this process reversible and allows the regeneration of the catalyst. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.