花粉热
过敏性炎症
过敏
炎症
免疫学
哮喘
医学
过敏反应
过敏性哮喘
过敏性结膜炎
作者
Stephen J. Galli,Mindy Tsai,Adrian M. Piliponsky
出处
期刊:Nature
[Springer Nature]
日期:2008-07-01
卷期号:454 (7203): 445-454
被引量:1414
摘要
Allergic disorders, such as anaphylaxis, hay fever, eczema and asthma, now afflict roughly 25% of people in the developed world. In allergic subjects, persistent or repetitive exposure to allergens, which typically are intrinsically innocuous substances common in the environment, results in chronic allergic inflammation. This in turn produces long-term changes in the structure of the affected organs and substantial abnormalities in their function. It is therefore important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reactivity.
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