化学
酰化
试剂
区域选择性
磷酸盐
结合
有机化学
反应速率常数
小学(天文学)
催化作用
动力学
天文
数学
量子力学
物理
数学分析
作者
Jolanta Wodzinska,Ronald Kluger
摘要
Acyl phosphate monoesters are readily prepared biomimetically activated anionic derivatives of carboxylic acids that react rapidly with amines in water to form amides. A plot of the logarithms of the rate constants for the reactions of a series of primary amines with benzoyl methyl phosphate depends on the pKa of the conjugate acids of the amines (βnuc ≈ 0.9). This provides a simple and quantitative basis for regioselective acylation with these reagents.
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