生物
鉴定(生物学)
基因
转化生长因子
遗传学
细胞生长
计算生物学
细胞生物学
植物
作者
Yong Zhou,Hidenori Kato,Kazuo Asanoma,Haruhiko Kondo,Takahiro Arima,Kiyoko Kato,Takao Matsuda,Norio Wake
出处
期刊:Genomics
[Elsevier]
日期:2002-11-01
卷期号:80 (5): 465-472
被引量:51
标识
DOI:10.1006/geno.2002.6860
摘要
We cloned the forkhead box C1 (FOXC1) gene, a member of the forkhead/winged-helix transcription factor family, as a transforming growth factor-beta1 (TGF-beta1) responsive gene. We showed that TGF-beta1 upregulated transcription of FOXC1 in several human cancer cell lines. Ectopic expression of FOXC1 cDNA in HeLa cells, which lack both copies of the FOXC1 allele, restores the potential of TGF-beta1 to inhibit cell growth by arresting cells in the G0/G1 phase. In addition, screens of primary endometrial and ovarian cancers revealed homozygous deletion of FOXC1 in 6.7% of them, one nonsense and one missense mutation of FOXC1, and transcriptional silencing in 11.7% of primary cancers. Evidence that a significant fraction of primary cancers exhibited somatic mutations suggests that FOXC1 functions as a tumor suppressor through TGF-beta1 mediated signals.
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