Integration of Pharmacokinetics and Pharmacodynamics into the Drug Development of Pegfilgrastim, a Pegylated Protein

This chapter contains sections titled: Introduction Overview of Filgrastim Pharmacokinetics The Making of Pegfilgrastim Preclinical Pharmacokinetics and Pharmacodynamics of Pegfilgrastim Pharmacokinetic and Pharmacodynamic Modeling Clinical Pharmacokinetics and Pharmacodynamics of Pegfilgrastim Basis for the Fixed-Dose Rationale Clinical Evaluation of the Fixed Dose Summary References