Structure–Stability Engineering of Pt‐Based and Fe–N–C Catalysts Toward Oxygen Reduction Reaction

active sites. Yet, their insufficient stability, primarily due to Fe leaching and protonation-induced deactivation, continues to hinder their practical applications. This review comprehensively summarizes recent advances in improving the stability and durability of Pt-based and Fe-N-C catalysts. For Pt-based systems, strategies include electronic structure regulation, entropy-driven alloying, and support-interface engineering. For Fe-N-C catalysts, progress has been made in graphitization enhancement, heteroatom doping, defect engineering, and dual-metal site incorporation, all aiming to suppress degradation pathways. Furthermore, structure-stability correlations revealed by experimental and computational studies provide mechanistic insights into degradation processes and stability-limiting factors. Special attention is given to the interactions among catalyst structure, electronic configuration, and electrochemical microenvironment, offering guidance for robust catalyst design. Finally, we discuss ongoing challenges and future opportunities for developing highly stable ORR catalysts, providing a roadmap toward next-generation cost-effective and durable ORR catalysts, and accelerating the industrial realization of sustainable energy conversion technologies.