The solid dispersion of resveratrol with enhanced dissolution and good system physical stability

Resveratrol is a non-flavonoid polyphenol with multiple biological activities; however, the specific properties of resveratrol present limitations for its clinical application. This study aimed to increase the dissolution of resveratrol based on solid dispersions which were prepared by the solvent method using Eudragit® E PO, polyethylene glycol 6000 (PEG 6000), Kollidon® 30 (PVP K30), and Soluplus®; meanwhile, physical stability of the developed solid dispersion systems were also evaluated. The miscibility of drug/polymers was evaluated by solubility parameters calculated by HSPiP software. Scanning electron microscopy (SEM), polarized light microscopy (PLM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), 1H nuclear magnetic resonance (NMR) and Fourier transform infrared spectroscopy (FTIR) were used to investigate the characteristics of solid dispersion. Dissolution tests and accelerated stability tests were also conducted. Analysis showed that resveratrol was amorphous in these solid dispersions with a ratio of 1:7 and exhibited better miscibility with PVP K30 and Soluplus® than Eudragit® E PO and PEG 6000. Stronger interactions were formed in the PVP K30 system and Soluplus® system. Both PVP K30 and Soluplus® systems exhibited excellent physical stability, but with low dissolution. In contrast, the Eudragit® E PO system exhibited weaker interaction and miscibility and significantly improved the dissolution of resveratrol by approximately 13-fold; there were no obvious changes in crystallinity or dissolution after storage.