A Progesterone Microneedle Patch for Self-Administration in the Prevention of Preterm Birth in a Mouse Model

Microneedle patches loaded with progesterone microemulsion were successfully developed, efficiently delivering progesterone and reversing RU486-induced preterm birth in mice. The MN patch was user-friendly, minimally harmful to skin tissue, safe, and non-toxic, representing a promising new approach for the clinical treatment of premature labor.