梭菌纲
艰难梭菌
细菌
厌氧菌
微生物学
恶二唑
化学
梭菌
生物
抗生素
遗传学
有机化学
标识
DOI:10.1021/acs.jmedchem.3c01778
摘要
The discovery of compound 57, a new, totally synthetic 1,2,4-oxadiazole antibacterial agent, is described. This oxadiazole displays highly selective, bactericidal killing of Clostridioides (Clostridium) difficile, the bacterium that causes C. difficile infection (CDI) in both hospital and community settings. The narrow spectrum of activity exhibited by 57 should avoid any disruption of commensal anaerobic bacteria in the gut microbiome, minimizing chances for recurrent CDI.
科研通智能强力驱动
Strongly Powered by AbleSci AI