医学
心力衰竭
射血分数
康复
心脏病学
内科学
炎症
祖细胞
血管内皮生长因子
病理生理学
内皮祖细胞
内皮功能障碍
血管内皮生长因子受体
物理疗法
干细胞
生物
遗传学
作者
Christos Kourek,Αlexandros Briasoulis,Eleftherios Karatzanos,Virginia Zouganeli,Katherina Psarra,Maria Pratikaki,Androula Alevra-Prokopiou,John Skoularigis,Αndrew Xanthopoulos,Serafim Nanas,Stavros Dimopoulos
摘要
Endothelial dysfunction and inflammation are common pathophysiological characteristics of chronic heart failure (CHF). Endothelial progenitor cells (EPCs) are recognized as useful markers of vascular damage and endothelial repair. The aim of this study was to investigate the effects of a cardiac rehabilitation program on EPCs and inflammatory profile in CHF patients of different severity. Forty-four patients with stable CHF underwent a 36-session cardiac rehabilitation program. They were separated into two different subgroups each time, according to the median peak VO2, predicted peak VO2, VE/VCO2 slope, and ejection fraction. EPCs, C-reactive protein (CRP), interleukin 6 (IL-6), interleukin 10 (IL-10), and vascular endothelial growth factor (VEGF) were measured. Flow cytometry was used for the quantification of EPCs. Mobilization of EPCs increased and the inflammatory profile improved within each severity group (p < 0.05) after the cardiac rehabilitation program, but there were no statistically significant differences between groups (p > 0.05). A 36-session cardiac rehabilitation program has similar beneficial effects on the mobilization of EPCs and on the inflammatory profile in patients with CHF of different severity.
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