Asymmetric synthesis of (R)-baclofen and (3S,4S)-tetflupyrolimet via “on water” organocatalytic addition reactions: a tip on catalyst screening

This work demonstrates asymmetric synthesis of the GABA derivative ( R )-baclofen and a new herbicidal mode-of-action inhibitor (3 S ,4 S )-tetflupyrolimet featuring low loading (0.5 mol%) organocatalytic addition reactions of dithiomalonates to nitrostyrenes under “on water” conditions.