Straightforward synthesis of unnatural α,α-disubstituted α-amino acid derivatives using readily accessible building blocks

Unnatural α,α-disubstituted α-amino acids have played a privileged role in drug discovery campaign, and the development of their efficient synthetic methods has thus received continuous attention. This review describes our originally developed synthetic methods of α,α-disubstituted α-amino acid derivatives using readily accessible building blocks. 1 Introduction 2 Asymmetric synthesis of α,α-disubstituted α-aryl α-amino acid derivatives from L-α-amino acids via “Memory of Chirality” 3 Synthesis of natural product-derived α,α-disubstituted α-amino acid derivatives by chemical engineering of natural product extracts 4 One-pot synthesis of α,α-disubstituted α-amino acid derivatives by ammonia-Ugi reaction