Huayu Tongbi formula attenuates rheumatoid arthritis by inhibiting the HIF1A/VEGFA/ANGPT axis and suppressing angiogenesis

HT has a promising effect on alleviating RA angiogenesis, at least in part through HIF1A-VEGFA-ANGPT axis inhibition, which reduces the cross-talk between RA-FLS and HUVECs. Our results suggest that HT is a drug candidate for the treatment of RA angiogenesis.