Association of higher triglyceride glucose index and triglyceride to high density lipoprotein cholesterol ratio with early-onset post-stroke depression

The prognosis of stroke is related to insulin resistance (IR), and post-stroke depression (PSD) is a prevalent psychological consequence following a stroke. The triglyceride-to-glucose (TyG) index and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio are simple and accurate markers of insulin resistance. However, the relationship between early-onset PSD and TyG index or TG/HDL-C ratio remains unknown. The Hamilton Depression Scale-17 item (HAMD-17) was used to assess the severity of depression. After two weeks of acute ischemic stroke (AIS), patients with HAMD-17 ≥ 7 were defined as early-onset post-stroke depression. Among the 543 recruited patients, a total of 206 (38%) patients were diagnosed with early-onset PSD. The logistic regression model determined that early-onset PSD was independently associated with the TyG index (odds ratio [OR], 1.915; 95% confidence interval [CI] 1.665-2.115, P < 0.001) and TG/HDL-C ratio (OR, 1.458; 95% CI 1.213-1.965, P = 0.002). The area under curve (AUC) of TyG index, TG/HDL-C ratio, and TyG index combined TG/HDL-C ratio to predict early-onset PSD was 0.765, 0.705, and 0.813, respectively. According to our research, the TG/HDL-C ratio and the TyG index could serve as independent risk factors and prediction indicators for early-onset PSD.