A Photo‐Responsive Hollow Manganese/Carbon Hybrid Nanosphere for Wound Disinfection and Healing

Abstract The emergence of multi‐drug resistant (MDR) bacteria poses a serious threat to human health. It has become imperative to develop efficient antimicrobial strategies. Here, a manganese‐doped dopamine‐derived hollow carbon sphere (MnO x /HNCS) is developed as a nanozyme and photothermal agent for the synergistic treatment of MDR bacterial infections. MnO x /HNCS possesses oxidase, superoxide dismutase, and peroxidase like activities and implements self‐cascading enzymatic catalysis to produce superoxide anion (O 2 •− ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (•OH). Importantly, near‐infrared light facilitates the electron transport of MnO x /HNCS, allowing it to exhibit stable photothermal effects and photo‐enhanced enzymatic activity. Thereby MnO x /HNCS displays a broad‐spectrum synergistic antibacterial efficiency in vitro against six MDR pathogens based on the above photo‐regulated properties. In vivo experiments further demonstrate the excellent antibacterial efficiency of MnO x /HNCS in the MDR bacteria‐infected wound model. Notably, MnO x /HNCS not only has excellent disinfection capacity, but also can accelerate wound healing by stimulating the deposition of the extracellular matrix and reepithelialization. This study proposes a promising antibiotics‐alternative broad‐spectrum antibacterial strategy and paves a new avenue for the establishment of multifunctional photo‐responsive synergistic therapeutic platform.