生物相容性
纳米技术
生物相容性材料
光子上转换
体内
化学
纳米颗粒
生物分子
表面改性
纳米医学
生物医学工程
材料科学
有机化学
医学
生物
离子
物理化学
生物技术
作者
Xu Wang,Jiatong Chen,Haomiao Zhu,Xueyuan Chen,Xiu‐Ping Yan
出处
期刊:Analytical Chemistry
[American Chemical Society]
日期:2013-10-15
卷期号:85 (21): 10225-10231
被引量:34
摘要
Bionanoparticles and nanostructures with high biocompatibility and stability, low toxicity, diversification of imaging modality, and specificity of targeting to desired organs or cells are of great interest in nanobiology and medicine. However, integrating all of these desired features into a single bionanoparticle, which can be applied to biomedical applications and eventually in clinical prediagnosis and therapy, is still a challenge. We herein report a facile one-step solvothermal approach to fabricate targetable and biocompatible β-NaYF4:Yb,Gd,Tm upconversion nanoparticles (UCNPs) with bimodal-signals (near-infrared (NIR) fluorescence and magnetic resonance (MR) signals) using hyaluronic acid (HA) as a multifunctional molecule. The prepared UCNPs with low toxicity are successfully applied for in vitro and in vivo targeted tumor imaging. The developed biomimetic surface modification approach for the synthesis of biomolecule-guided multifunctional UCNPs holds great potential applications in medical diagnostics and therapy.
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