OBJECTIVE The application value in the treatment of vulvovaginal candidiasis fluconazole.METHODS Non-pregnant patients with vulvovaginal candidiasis randomly divided into two groups.The observation group oral fluconazole for the treatment(50 cases).Miconazole suppostitories external control group(50 cases).Analysis the efficacy,the acceptance of patients and adverse reactions.RESULTS Comparison of clinical effect:apparent effect was higher significantly in the observation group than that in the control group(P0.05).The acceptance rate of two types treatment had difference significant(P0.05).CONCLUSION The time of oral fluconazole treatment the vulvovaginal candidiasis was short,easy to accept,light adverse reactions,well tolerated,worthy of clinical use.