Synthesis, crystal structure, and bioactivity of N-dichloroacetyl diazabicyclo compounds

Abstract A short and efficient route to synthesis of a series of N -dichloroacetyl diazabicyclo derivatives has been developed. The compounds were obtained by cycloaddition of levulinic acid or ester with diamine, followed by acylation with dichloroacetyl chloride. All products were characterized by IR, 1 H NMR, 13 C NMR, MS, and elemental analysis. The single crystal of compound 4c was determined by X-ray crystallographic analysis. All compounds were tested for their herbicide safeners activity of protecting maize from injury with acetochlor.