Objective To discuss the treatment of hyponatremia in patients with a complication of hydrocephalus following intracranial infection.Methods A total of 26 cases of hyponatremia with a complication of hydrocephalus following intracranial infection were analyzed retrospectively.ResultsSymptoms were improved significantly after the treatment,and the serum sodium level and the plasma osmolality returned to the normal level gradually at 3 d to 8 d.Conclusion Cerebral salt-wasting is the potential cause of hyponatremia with a complication of hydrocephalus following intracranial infection.The prognosis is usually good after appropriate treatment.